Endocrine Abstracts

We aimed to assess the effect of sleeve gastrectomy (SG) on the metabolic and gut microbiota profiles in non-diabetic obese patients with different grade of insulin resistance (IR).Methods: Prospective study of 22 morbid non-diabetic obese patients (77.2% women, age 47.13±9.51 years, basal BMI 45.59±4.99 kg/m2, 11 IR and 11 non-IR) undergoing SG. A fasting blood sample was collected at baseline and at 6 months post-SG for the determi...

Background: Obesity can lead type 2 diabetes (T2D), however there are patients with obesity who present euglycemia. The mechanisms by which T2D appears have not been fully elucidated. Oncostatin m (OSM) is a proinflammatory cytokine, member of the IL-6 family, which is increased in obesity in mice and humans, and impairs browning in mice. Here, we aim at evaluating the potential role of OSM in the development of T2D in patients with obesity.Material and ...